A new study shows how the epigenetic aging clocks respond to interventions that promote longevity. The paper looks at whether epigenetic clocks actually move when you try to slow aging.

https://www.nature.com/articles/s41591-026-04562-9#Sec14

The study shows:

Pharmacological interventions (anti-TNF, metformin, semaglutide, etc.) produce the largest and most consistent drops. Lifestyle (especially Mediterranean-style diets) is next. Supplements and most procedures are weaker and more mixed.

Effects are bigger in people who already have disease than in healthy volunteers.

The top 8 interventions are:

Strongest multi-clock, multi-study consistency: Anti-TNF and Mediterranean diets.

Best single-agent pharma signal among the ones tested: Metformin.

Disease populations generally showed larger drops than healthy volunteers.