• Brain aging is a major risk factor for Alzheimer’s, with an aged brain carrying a risk similar to the APOE4 gene, while a youthful brain offers protection like APOE2.
• Multiple aged organs (5-7 or 8+) significantly increase mortality risk (HR 4.5 and 8.3, respectively).
• Youthful brains and immune systems are key to longevity, reducing mortality risk by up to 56% when both are healthy.
• Lifestyle factors like smoking, alcohol, and diet impact organ aging, suggesting modifiable ways to boost healthspan.

This opens doors to monitoring organ health and targeting interventions for a longer, healthier life! Read more: https://doi.org/10.1038/s41591-025-03798-1